Thyroid function in growth-hormone-transgenic coho salmon (<i>Oncorhynchus kisutch</i>)
Bibliographic record
Abstract
We measured growth rate, plasma thyroxine (T 4 ) and 3,5,3'-triiodothyronine (T 3 ) concentrations, and liver and whole-brain T 4 and T 3 deiodination activities in yearling non-transgenic coho salmon, Oncorhynchus kisutch (Walbaum, 1792), fed a satiation ration (NT S ) and in growth-hormone (GH)-transgenic salmon fed for 63 d with either a satiation ration (T S ) or pair-fed the satiation ration consumed by NT S fish (T NT ). Daily feed intake and specific growth rate for T S fish were significantly enhanced and approximately double those for T NT and NT S fish. There were no differences among groups in plasma T 4 concentration or liver T 4 outer-ring deiodination activity, but for both T S and T NT fish, plasma T 3 concentrations were higher and liver T 4 and T 3 inner-ring deiodination activities were lower than for NT S fish. Whole-brain deiodination activities did not differ between T S and NT S fish. We conclude that the elevated plasma T 3 concentrations of GH-transgenic salmon neither are driven by elevated plasma T 4 concentrations nor are they the result of increased hepatic conversion of T 4 to T 3 by outer-ring deiodination. Instead they can be explained, at least in part, by reduced hepatic degradation of T 3 to 3,3'-diiodothyronine by inner-ring deiodination. These changes in T 4 and T 3 metabolism are tightly linked to the GH-transgenic state and not to food intake or growth rate.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".