Evaluación de los efectos de dos protocolos anestésicos aplicados durante ovariohisterectomía sobre hemograma, creatinina, BUN, ALT y FA en hembras caninas
Bibliographic record
Abstract
En este estudio se evaluaron dos protocolos anestesicos para ovariohisterectomia (OVH) en diez hembras caninas raza Labrador, distribuidas al azar en dos grupos de cinco animales cada uno, y se asigno, al azar, unprotocolo diferente a cada grupo: Grupo 1: fentanilo + etomidato, Grupo 2: fentanilo + tiopental. En ambos grupos el mantenimiento se hizo con isofluorano. En cada caso se evaluaron sus efectos sobre el hemograma, la alanina-aminotransferasa (ALT), fosfatasa alcalina (FA), nitrogeno ureico en sangre (BUN) y creatinina, tomando muestras 24 horas antes, 2 y 24 horas despues de la anestesia y cirugia de OVH. En cuanto a la linea roja, los valores disminuyeron significativamente en el Grupo 1 (p≤0,05). Por el contrario, en la linea blanca, la mayoria de sus variables no mostraron cambios importantes; sin embargo, los neutrofilos aumentaron significativamente 24 horas despues de la anestesia y cirugia de OVH (p≤0,05). En cuanto al aumento de los valores de ALT atribuibles a los protocolos anestesicos, estos no tuvieron efectos clinicamente significativos. Los cambios de los valores en la creatinina no fueron clinicamente relevantes. Las demas variables estuvieron dentro de los parametros normales, sin cambios significativos entre los protocolos y tiempos de muestreo. En conclusion, en las condiciones de este estudio, las combinaciones anestesicas usadas no produjeron alteraciones fuera de los parametros fisiologicos de las variables sanguineas y de bioquimica analizadas; sin embargo, se recomienda tener especial cuidado con el uso de etomidato como inductor en paciente con disminucion de globulos rojos. Abstract In this study two different anesthetic protocols for ovariohysterectomy (OVH) were evaluated in ten female Labrador dogs, randomly distributed into two groups of 5 animals each, and were assigned at random, a different protocol to each group: Group 1 (fentanyl + etomidate), Group 2 (fentanyl + thiopental). In both groups the maintenance was done with isofluorano. In each case its effects were evaluated on hemogram, alanine-aminotransferasa (ALT), alkaline phosphatase, blood urea nitrogen (BUN) and creatinine, taking samples 24 hours before, 2 and 24 hours after the anesthesia and OVH surgery. As to the red line cells, values declined were significant in Group 1(p≤0,05). In contrast, in the white line cells most of its variables showed no significant changes; however, neutrophils increased markedly 24 hours after anesthesia and OVH surgery (p≤0,05). As for the increased of ALT values attributable to the anesthetic protocols, did not have significant clinical effects. Changes in creatinine values were not clinically relevant. The other variables were within the normal parameters, with no significant changes between the groups and time of sampling. In conclusion in conditions of this study, used anesthetic combinations produced no changes on outside on the physiological parameters of the blood cells and biochemical analyzed; however it is recommend to take special care with the use of etomidate for induction in patients with reduced red blood cells.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".