Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin
Bibliographic record
Abstract
Letters6 November 2007Bridging Low-Molecular-Weight Heparin for Temporary Interruption of WarfarinA. M. Shojania, MDA. M. Shojania, MDFrom St. Boniface General Hospital, Winnipeg, Manitoba R2H 2A6, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent article on preoperative anticoagulant activity of low-molecular-weight heparin (LMWH) after a standardized bridging regimen, O'Donnell and colleagues (1) indicated the following: warfarin was withheld 4 to 5 days before the planned procedure; enoxaparin, 1 mg/kg of body weight twice daily, was given to patients 3 days before surgery; and the final dose of enoxaparin was given the night before surgery. They conclude that because the mean anti–factor Xa level before surgery was 0.6 U/mL and anti-Xa levels were 0.5 U/mL or greater in 68% of the patients, preoperative bridging therapy will result in a ...References1. O'Donnell MJ, Kearon C, Johnson J, Robinson M, Zondag M, Turpie I, et al. Brief communication: preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin. Ann Intern Med. 2007;146:184-7. [PMID: 17283349] LinkGoogle Scholar2. Hirsh J, Raschke R. Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126:188S-203S. [PMID: 15383472] CrossrefMedlineGoogle Scholar3. Shojania AM. More on: is laboratory monitoring of low-molecular-weight heparin necessary? [Letter]. J Thromb Haemost. 2004;2:2276-7. [PMID: 15613053] CrossrefMedlineGoogle Scholar4. Ferreira I, Dos L, Tornos P, Nicolau I, Permanyer-Miralda G, Soler-Soler J. Experience with enoxaparin in patients with mechanical heart valves who must withhold acenocumarol. Heart. 2003;89:527-30. [PMID: 12695457] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: A. M. Shojania, MDAffiliations: From St. Boniface General Hospital, Winnipeg, Manitoba R2H 2A6, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Preoperative Anticoagulant Activity after Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin Martin J. O'Donnell , Clive Kearon , Judy Johnson , Marlene Robinson , Michelle Zondag , Irene Turpie , and Alexander G. Turpie Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin Martin J. O'Donnell , Clive Kearon , and Alexander G. Turpie Metrics 6 November 2007Volume 147, Issue 9Page: 671KeywordsAnticoagulantsBody weightConflicts of interestHemorrhageHeparinInternational normalized ratioLow molecular weight heparinPathologistsSurgeryVitamin K ePublished: 6 November 2007 Issue Published: 6 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.007 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".