Bibliographic record
Abstract
Hypophosphatasia is a rare and lethal metabolic bone disease characterised by low or absent serum and tissue-alkaline phosphatase activities resulting in insufficient bone mineralisation. Hypophosphatasia has been reported throughout the world and affects all races; however, it is especially prevalent in Manitoba, Canada, where about one in 25 individuals is a carrier and 1: 2.500 newborns manifest severe disease. Six forms of hypophosphatasia have been identified. The perinatal (lethal), infantile, childhood and adult types are distinguished from one another by the age at which clinical manifestations and bone lesions are recognised. Patients with dental manifestations but no skeletal disease are considered to have odontohypophosphatasia. Pseudohypophosphatasia is a rare variant of hypophosphatasia characterised by normal serum alkalinephosphatase (ALP) activity (1). The severe infantile form of hypophosphatasia is autosomal-recessively inherited and is lethal in the neonatal period (2). We report a neonate with congenital hypophosphatasia in which prenatal diagnosis could not be carried out, in spite of the termination of the mother’s former pregnancy because of abnormal skeletal development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".