Nanoscale Stripe Patterns in Phospholipid Bilayers Formed by the Langmuir−Blodgett Technique
Bibliographic record
Abstract
A new methodology has been developed to create an extensive pattern of parallel stripes, ∼150−250 nm wide, in phospholipid bilayers supported on mica. These striped bilayers are prepared by the Langmuir−Blodgett (LB) film technique. A striped monolayer consisting of two phospholipids in different states (condensed and liquid-expanded) is used to direct the deposition of the solid- and liquidlike phases of a second mixed monolayer during LB transfer. We also demonstrate that bilayer stripes can be generated by the condensation of phospholipids over the solidlike stripe domains of the underlying monolayer for a one-component film deposited just below the liquid-expanded-to-liquid-condensed phase transition pressure. Nonionic detergent extraction of the liquidlike phase from these LB films resulted in bilayer-thick phospholipid stripes separated by a mica surface. A periodic array of grooves was produced by the selective adsorption of protein onto the mica regions of the detergent-treated bilayer. The LB film deposition of binary mixtures of solid-phase- and fluid-phase-forming phospholipids constitutes a novel strategy to create linear surface patterns that can be used to direct the deposition of molecules.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".