Effects of physiological state, mass change and diet on plasma metabolite profiles in the western sandpiper<i>Calidris mauri</i>
Bibliographic record
Abstract
We used a food restriction/refeeding protocol to put birds through a controlled cycle of mass loss and mass gain to investigate the effects of rate and phase of mass change on plasma metabolite levels in relation to diet. Despite marked differences in fat content of the two diets (18% vs 4%) mean rate of mass loss or mass gain was independent of diet. There was also no effect of diet on plasma levels of any of the four measured metabolite (triglyceride, glycerol, uric acid and beta-OH-butyrate) during mass loss. However, during mass gain birds on the low fat diet had higher plasma levels of triglyceride and uric acid and lower beta-OH-butyrate than birds gaining mass on the high-fat diet. Thus, diet composition can affect plasma metabolite profiles independently of differences in rates of mass change. Nevertheless, certain plasma metabolites were related to variation in rates of mass change across physiological states. Glycerol levels were negatively related to the rate of mass change (independent of diet), and butyrate was negatively related to the rate of mass change on both diets (though the slope of this relationship was diet dependent). Uric acid was positively related to the rate of mass change but only for birds on the low-fat diet. Our study therefore confirms that measurement of plasma metabolites can provide robust information on physiological state (gain, loss) and the rate of mass change (e.g. in free-living birds caught only once) although researchers should be cogniscent of potential confounding effects of diet composition for certain metabolites, both for field studies and for future experimental validations of this technique.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".