Mechanotransduction and blood fluid dynamics in developing blood vessels
Bibliographic record
Abstract
Abstract The vascular endothelium is the interface in the cardiovascular system between the blood vessel wall and the flowing blood. As such, these cells are exposed to both shear stress and circumferential stretch. Though a lot is known about the regulation of gene expression by flow in mature vascular networks, very little is known in developing vessels. Most vascular networks in the adult are homeostatic, exhibiting very low rates of endothelial cell replication and turnover. In disease states such as cancer or macular degeneration, the vascular system is able to recapitulate embryonic growth and reinduce blood vessel growth. The vasculature that develops is similar to the embryonic vasculature, and so many have used knowledge of embryonic development to interpret pathological blood vessel growth. It was believed until recently that the embryonic vasculature was not sensitive to flow. We recently showed that shear stress is necessary for proper vascular development. We therefore review the role of blood flow and mechanical forces in vascular development. We examine the pattern and magnitude of flow present in primitive vascular networks as well as exploring gene regulation by shear stress in both in vitro and in vivo embryonic systems.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".