The effects of right and left amygdala kindling on the female reproductive system in rats
Bibliographic record
Abstract
PURPOSE: Women with epilepsy often have comorbid reproductive dysfunction. Using the amygdala kindling model in rats, the present study examined the effects of seizures of limbic origin on the reproductive system. METHODS: Female Wistar rats were kindled from the left or right basolateral amygdala to a criterion of 40 stage V seizures. Sham-kindled subjects were handled but not stimulated. Vaginal cytology was assessed daily for the duration of the study. Twenty-four hours following the last kindled seizure, kindled subjects and their yoked controls were sacrificed and their brains and serum were extracted. RESULTS: Kindled subjects displayed significantly more abnormal estrous cycle days and significantly elevated levels of estradiol as compared to controls. There was, however, no total suppression of cycling. No laterality effects were seen for estrous cycle abnormalities. DISCUSSION: Seizures of limbic origin cause changes in estrous cycling. Right and left kindling seem to have a similar effect. These findings highlight the need for clinicians to monitor reproductive issues among individuals with epilepsy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".