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Record W2035513334 · doi:10.1016/j.jacc.2010.06.022

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

2010· article· en· W2035513334 on OpenAlexaff
Themistocles L. Assimes, Hilma Hólm, Sekar Kathiresan, Muredach P. Reilly, Guðmar Þorleifsson, Benjamin F. Voight, Jeanette Erdmann, Christina Willenborg, Dhananjay Vaidya, Changchun Xie, C. C. Patterson, Thomas M. Morgan, Mary Susan Burnett, Mingyao Li, Mark A. Hlatky, Joshua W. Knowles, John R. Thompson, Devin Absher, Carlos Iribarren, Alan S. Go, Stephen P. Fortmann, Stephen Sidney, Neil Risch, Hua Tang, Richard M. Myers, Monika Stoll, Svati H. Shah, Guðmundur Þorgeirsson, Karl Andersen, Aki S. Havulinna, J. Enrique Herrera, Nauder Faraday, Yoonhee Kim, Brian G. Kral, Rasika A. Mathias, Ingo Ruczinski, Bhoom Suktitipat, Alexander F. Wilson, Lisa R. Yanek, Lewis C. Becker, Patrick Linsel‐Nitschke, Wolfgang Lieb, Inke R. König, Christian Hengstenberg, Marcus Fischer, Klaus Stark, Wibke Reinhard, Janina Winogradow, Martina Grassl, Anika Großhennig, Michael Preuß, Stefan Schreiber, H-Erich Wichmann, Christa Meisinger, Jean Yee, Yechiel Friedlander, Ron Do, James B. Meigs, Gordon H. Williams, David M. Nathan, Calum A. MacRae, Liming Qu, Robert L. Wilensky, William Matthai, Atif Qasim, Håkon Håkonarson, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Joseph Lindsay, Ron Waksman, Christopher W. Knouff, Dawn Waterworth, Max Walker, Vincent Mooser, Jaume Marrugat, Gavin Lucas, Isaac Subirana, Joan Sala, Nicola Martinelli, Oliviero Olivieri, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Candace Guiducci, Daniel B. Mirel, Melissa Parkin, Joel N. Hirschhorn, Rosanna Asselta, Stefano Duga, Mark J. Daly, Shaun Purcell, Sandra Eifert, Peter S. Braund, Benjamin J. Wright, Anthony J. Balmforth, Stephen G. Ball, Willem H. Ouwehand, Panos Deloukas, Michael Scholz, François Cambien, Andreas Huge, Thomas Scheffold, Veikko Salomaa, Domenico Girelli, Christopher B. Granger, Leena Peltonen, Pascal McKeown, David Altshuler, Olle Melander, Joseph M. Devaney, Stephen E. Epstein, Daniel J. Rader, Roberto Elosúa, James C. Engert, Sonia S. Anand, Alistair S. Hall, Andreas Ziegler, Christopher J. O’Donnell, John A. Spertus, David S. Siscovick, Stephen M. Schwartz, Diane M. Becker, Unnur Þorsteinsdóttir, Kāri Stefánsson, Heribert Schunkert, Nilesh J. Samani, Thomas Quertermous

Bibliographic record

VenueJournal of the American College of Cardiology · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicrotubule and mitosis dynamics
Canadian institutionsMcGill UniversityHamilton Health SciencesMcMaster UniversityPopulation Health Research Institute
FundersNational Heart, Lung, and Blood InstituteBERLIN-CHEMIEEconomic and Social Research CouncilGlaxoSmithKline
KeywordsCoronary artery diseaseMedicineInternal medicineAlleleSingle-nucleotide polymorphismDiseasePolymorphism (computer science)Case-control studyConfidence intervalOncologyGenotypeGeneticsBiologyGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.009
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.259
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations87
Published2010
Admission routes1
Has abstractno

Explore more

Same venueJournal of the American College of CardiologySame topicMicrotubule and mitosis dynamicsFrench-language works237,207