A Case Report on the Effect of Everolimus in Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex
Bibliographic record
Abstract
Tuberous Sclerosis (TS) is a well known disorder which manifests with benign tumors in various organ systems, including angiomyolipomas (AML) of the kidneys. The mTOR inhibitors have emerged as a potential systemic treatment strategy to halt the growth of renal angiomyolipomas and to prevent life threatening complications such as bleeding. This report shows that everolimus treatment may have an impact on size and density of renal AML lesions which may lead to prevention or delay the development of renal cell carcinoma as well as prevent bleeding from the renal AML lesions. A 20-year-old Hispanic female and a 24-year-old Asian female both with sporadic TS were administered daily oral everolimus therapy. Both showed stability in their renal AML lesions and notable improvement of their extra-renal TS manifestations. Treatment with daily everolimus may lead to reduction in size and/or decreases in density or renal AML lesions. This may have an impact on the risk of developing renal cell carcinoma as well as preventing bleeding from renal AML lesions. J Med Cases. 2014;5(3):129-136 doi: http://dx.doi.org/10.14740/jmc1665w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.020 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".