Creatine monohydrate does not increase strength in patients with hereditary neuropathy
Bibliographic record
Abstract
Creatine is a guanidino compound produced endogenously by the liver and consumed in diets inclusive of meat and fish. Creatine monohydrate (CM) supplementation increases lean body mass, high-intensity power output, and strength in young healthy volunteers.1 Clinical trials of CM supplementation have demonstrated modest improvements in muscular strength, endurance, and activities of daily living (ADL) for patients with neuromuscular disorders.2-4⇓⇓ We evaluated the potential benefits of short-term CM supplementation for patients with hereditary motor sensory neuropathy (HMSN) type I and II. ### Subjects. Thirty-nine subjects (mean age 42.5 years) with HMSN types I (n = 34) and II (n = 5) gave their informed consent to take part. The diagnosis of HMSN I or II was confirmed from the clinical presentation, family history, as well as confirmatory genetic or electrophysiologic assessment. ### Study design. A double-blinded, placebo-controlled, crossover design was used. Subjects were randomized to CM or placebo for 1 month, followed by a 5-week washout period. They then …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".