Will my Rett syndrome patient walk, talk, and use her hands?
Bibliographic record
Abstract
First recognized by Andreas Rett in 1966 and rediscovered in 1983,1 Rett syndrome (RS) is among the most common causes of mental retardation, affecting upwards of 1 in 10,000 girls. Extensive clinical characterization has revealed a distinctive clinical entity. Stereotypic almost constant hand-rubbing in wakefulness is its most recognizable symptom. Social anxiety akin to autism is another. The latter increases the former, and the girls appear as though they are, and perhaps they truly are, wringing their hands in anxiety, hence the use of the term hand-wringing. The disease begins in mid-infancy with decelerating head growth after a period of normal development. The neurologic regression starts between 6 and 36 months with developmental arrest, and loss of or reduction in hand use, speech, and communication skills, and social interest. Additional features include a typical pattern of disease progression with the regression reaching a plateau and not progressing further, in contradistinction to other neurodegenerative diseases, and autonomic abnormalities including irregular breathing and cold blue extremities.2 RS is caused by mutations in the X-linked MECP2 gene, which encodes the …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.008 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.016 | 0.012 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".