SP38 Cardiovascular Reactivity during Stress in Premenopausal and Postmenopausal Women
Bibliographic record
Abstract
Objective: Following menopause, women are at increased risk for cardiovascular disease. The present study assessed haemodynamic changes following menopause, with a focus on systemic vascular resistance (SVR) at rest and during stress. Plasma epinephrine and norepinephrine and cardiovascular adrenergic receptor (AR) function were also examined as potential mediators of haemodynamic changes. Method: A total of 94 women (N = 47 premenopausal; N=47 post-menopausal) completed a laboratory protocol comprised of a resting baseline and 4 mental stress tasks (anger interview, reaction-time shock-avoidance, mirror trace, and foot cold pressor). Heart rate, blood pressure (BP), cardiac output (CI) and systemic vascular resistance (SVRI), indexed for body surface area, were recorded each minute over the last three minutes of the resting baseline and during each minute of the 4 stress tasks. BP was measured utilizing an automatic auscultatory BP monitor. Impedance cardiography signals were recorded. To obtain plasma epinephrine and norepinephrine values, blood was sampled continuously from a cannula inserted into a forearm vein and connected by heparin-treated polyethylene tubing to a blood withdrawal pump. Measurements were averaged to yield baseline and task values. Cardiovascular AR function was assessed in a separate session using infusions of isoproterenol and phenylephrine.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".