Bibliographic record
Abstract
Hypoxia is a condition in which there is an insufficiency of oxygen for normal cell operation. It is directly related to diminished oxygen supply, usually because of restricted/insufficient blood circulation or defective oxygen transport and release. However, in absolute terms, cells in a small size animal may experience hypoxia with an oxygen supply comparable to that of normalcy in larger animals. The question is, essentially, the alometrically-related metabolic rate which translates into the actual individual cell metabolism. Cells in large animals consume less oxygen in vivo than their smaller animal counterparts, but this is not translated into hypoxia in the former. The critical point is not the absolute oxygen supply but the relationship of this to the incorporation of substrates to oxidize. It is the alteration of the ratio between oxidizable substrates and oxygen availability, the factor eliciting the ravages of hypoxia. The normal function of the circulatory system maintains a balanced supply of both terms of the equation; however, substrate oversupply, such as that experienced by adipose tissue in the metabolic syndrome may break the equilibrium, eliciting hypoxia and acidosis, which may derive into inflammation and further cell and tissue damage. doi:10.4021/j em 52w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.001 | 0.013 |
| Scholarly communication | 0.004 | 0.006 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.005 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".