<i>In vitro</i>study on cytotoxic effect and anti-DENV2 activity of<i>Carica papaya</i>L. leaf
Why this work is in the frame
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Bibliographic record
Abstract
Dengue fever is the most deleterious and rapidly spreading mosquito-borne viral disease, and to date it has resisted attempts to eradicate it. Carica papaya L. leaf extract is traditionally used to cure dengue fever and its associated symptoms. However, no in vitro studies have been reported for the anti-dengue efficacy of this extract. So, the present study attempted to determine the phytochemicals present in Carica papaya L. leaf extracts, as well as their cytotoxic effect and anti-DENV2 activity on the LLC-MK2 cell line. Methanolic extracts, containing triterpenoids and flavonoids, showed cytotoxic effects (CC50=0.6156 mg ml−1), whereas a chloroform extract, rich in alkaloids, tannin and saponin, was non-cytotoxic (CC50= >1 mg ml−1) to LLC-MK2 cells and it showed inhibitory activity (EC50= >1 mg ml−1) against DENV2 with a selectivity index value of±>1. This indicates that the crude chloroform extract has moderate or less inhibitory action against DENV2 growth in in vitro conditions. The current study will help in the future development of new and novel drugs against dengue pathogens with high efficacy.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it