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Unbiased tensor-based morphometry: Improved robustness and sample size estimates for Alzheimer's disease clinical trials

2012· article· en· W2040016992 on OpenAlexfundno aff
Xue Hua, Derrek P. Hibar, Christopher R. K. Ching, Christina P. Boyle, Priya Rajagopalan, Boris A. Gutman, Alex Leow, Arthur W. Toga, Clifford R. Jack, Danielle Harvey, Michael W. Weiner, Paul M. Thompson

Bibliographic record

VenueNeuroImage · 2012
Typearticle
Languageen
FieldMedicine
TopicAdvanced Neuroimaging Techniques and Applications
Canadian institutionsnot available
FundersNational Institute on AgingNational Institutes of HealthGenentechU.S. National Library of MedicineIXICONational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchUniversity of California, Los AngelesServierEisaiNorthern California Institute for Research and EducationUniversity of California, San DiegoPfizerBiogenBioClinicaAlzheimer's AssociationAmorfix Life SciencesNational Center for Research ResourcesF. Hoffmann-La RocheMedpaceAstraZenecaEli Lilly and CompanyBristol-Myers SquibbBayer HealthCareMeso Scale DiagnosticsAlzheimer's Disease Neuroimaging InitiativeNovartis Pharmaceuticals CorporationSynarc
KeywordsNeuroimagingAlzheimer's Disease Neuroimaging InitiativeSample size determinationStatistical powerMagnetic resonance imagingAtrophyRobustness (evolution)Clinical trialPsychologyMedicineAlzheimer's diseaseDiseaseNeuroscienceInternal medicineStatisticsRadiologyMathematicsBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.022
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.286
Threshold uncertainty score0.987

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.022
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.325
GPT teacher head0.485
Teacher spread0.160 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations123
Published2012
Admission routes1
Has abstractno

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