Beneficial Effects on Glucose Metabolism of Chronic Feeding of Isomaltulose versus Sucrose in Rats
Bibliographic record
Abstract
BACKGROUND/AIMS: Isomaltulose (alpha-D-glucosylpyranosyl-1,6-D-fructofuranose) is a natural disaccharide used in human nutrition. It is structurally related to sucrose, but more slowly hydrolyzed and absorbed. Because this sugar's metabolic effects are poorly characterized, we compared the effects of chronic ad libitum access to high-isomaltulose and high-sucrose diets on glucose metabolism in rats. METHODS: Adult male rats were offered 62% isomaltulose, sucrose or starch diets ad libitum for 26 (trial 1) or 56 (trial 2) days. After 2- to 3-week adaptation, plasma glucose, fructose and insulin were measured after test meals of the adaptation diet. RESULTS: The main finding was that both plasma glucose and plasma insulin concentrations were transiently but markedly increased after sucrose test meals compared to isomaltulose or starch meals. These differences were not associated with consistent differences in food intake, body weight gain or adiposity. CONCLUSIONS: Chronic isomaltulose feeding has beneficial effects on postprandial glucose metabolism in comparison to sucrose feeding in rats, although the effects are modest. Further work is warranted to determine whether substitution of isomaltulose for sucrose or other sweet carbohydrates might be therapeutically useful in patients with, or at risk for, insulin resistance or type 2 diabetes mellitus.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".