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Selective inhibition of BET bromodomains

2010· article· en· 4,296 citations· W2041535798 on OpenAlex· 10.1038/nature09504

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Protein Degradation and Inhibitors
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
National Cancer InstituteCanadian Institutes of Health ResearchU.S. Public Health ServiceCancer Research UKWellcome Trust
Keywords
BromodomainBRD4EpigeneticsChromatinBET inhibitorSmall moleculeHistoneFusion proteinChemistryBinding siteComputational biologyAcetylationBiologyCell biologyCancer researchBiochemistryGene
Has abstract in OpenAlex
no