Plasma Norepinephrine, Epinephrine and Dopamine Responses to Intracerebral Administration of a Met-Enkephalin Analog, D-Ala <sup>2</sup> -Met-Enkephalinamide, in Rats
Bibliographic record
Abstract
Intracisternal (i.c.) administration (25 microgram or 42.6 nmol) of the potent met-enkephalin analog, D-ala2-met-enkephalinamide (DALA) in adult male rats increased plasma concentrations of norepinephrine and epinephrine for more than 90 min. Intra-arterial (i.a.) administration of the same or a fourfold larger dose was without any effect. I.c. administration of human beta-endorphin (25 microgram or 7.25 nmol) produced much greater plasma responses of all three catecholamines than seen with DALA. An i.a. dose of naloxone, which had been shown previously to inhibit the plasma catecholamine responses to beta-endorphin, failed to inhibit plasma catecholamine responses to DALA. Also, naloxone alone failed to alter the basal plasma concentrations of the three catecholamines. The data are consistent with an effect of DALA acting at a presently unknown brain site to increase central sympathetic outflow, thus increasing plasma concentrations of norepinephrine and epinephrine. It appears probable that this effect of DALA is mediated at a different opioid receptor and perhaps a different brain site than the effect of beta-endorphin to increase central sympathetic outflow.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".