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Record W2042560956 · doi:10.1038/ng.2985

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

2014· review· en· W2042560956 on OpenAlexfundno aff
Ben Zhang, Wei-Hua Jia, Koichi Matsuda, Sun‐Seog Kweon, Keitaro Matsuo, Yong-Bing Xiang, Aesun Shin, Sun Ha Jee, Dong-Hyun Kim, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Yanfeng Zhang, Chun Li, Bingshan Li, Yan Guo, Zefang Ren, Bu-Tian Ji, Zhi-Zhong Pan, Atsushi Takahashi, Min‐Ho Shin, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Soriul Kim, Yoon-Ok Ahn, Andrew T. Chan, Jenny Chang‐Claude, Martha L. Slattery, Stephen B. Gruber, Fredrick R. Schumacher, Stephanie L. Stenzel, Graham Casey, Hyeong-Rok Kim, Jin‐Young Jeong, Ji Won Park, Hong-Lan Li, Satoyo Hosono, Sanghee Cho, Michiaki Kubo, Xiao‐Ou Shu, Yi-Xin Zeng, Wei Zheng

Bibliographic record

VenueNature Genetics · 2014
Typereview
Languageen
FieldMedicine
TopicGenetic factors in colorectal cancer
Canadian institutionsnot available
FundersDivision of Cancer Epidemiology and Genetics, National Cancer InstituteSchool of Medicine, University of North Carolina at Chapel HillNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteNational Institute on AgingNational Key Research and Development Program of ChinaFaculty of Medicine, Memorial University of NewfoundlandMedical Center, University of PittsburghAlbert Einstein College of Medicine, Yeshiva UniversitySchool of Medicine, Vanderbilt UniversitySchool of Medicine, New York UniversityUniversity of TorontoMemorial University of NewfoundlandUniversity of MelbourneMinistry of Education, Culture, Sports, Science and TechnologyUniversity of PittsburghMassey UniversityYork UniversityNational Institute of Environmental Health SciencesOttawa Hospital Research InstituteDeutsches KrebsforschungszentrumJapan Society for the Promotion of ScienceCase Comprehensive Cancer Center, Case Western Reserve UniversityOhio State UniversityNational Research FoundationBrigham and Women's HospitalKaiser PermanenteMassachusetts General HospitalCase Western Reserve UniversityNational Natural Science Foundation of ChinaUniversity of WashingtonYeshiva UniversityNational Institutes of HealthUniversity of Southern CaliforniaNational Research Foundation of KoreaDepartment of Internal Medicine, University of UtahVanderbilt University
KeywordsBiologyColorectal cancerGeneticsScale (ratio)East AsiaEvolutionary biologyCancerChinaCartography

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.324
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations243
Published2014
Admission routes1
Has abstractno

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