P1.12 B-PROOF: IS ARTERIAL STIFFENING ASSOCIATED WITH HOMOCYSTEINE?
Bibliographic record
Abstract
Objective: Pulse pressure (PP), as a marker of large artery stiffness, is a risk factor for target organ damage in hypertension (HT).We hypothesized that elevated PP, as a marker of enhanced arterial stiffness, may be correlated with specific early target organ damage (TOD) of the brain -mild cognitive impairment (MCI).Design and methods: 148 treated HT patients (Pts) -males 51 (34.5%), females 97 (65.5%) with mean age 64.16Æ11.18years and mean hypertension history 13.1Æ11.05years were included.Full medical history, esp.HT history, physical examination and laboratory screening were gathered.Only Pts in sinus rhythm were included.We screened the Pts for MCI with a battery of neuropsychological tests (NPTs): Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).Ambulatory Blood Pressure Monitoring was conducted: mean day PP was 56.85Æ12.02mmHg and mean night PP -55.15Æ16.13mmHg.Results: Regression analysis found correlation between day and night PP and NPTs' results.With Mann-Whitney Test (a<0.05)we found that there is a significant difference (sig.0.023 for MMSE) in the mean values of the NPTs' results between the groups with PP>50 and PP 50 mmHg.Again with Mann-Whitney Test we assessed the significance of the difference between mean values of day-PP (sig.0.01) and night-PP (sig.0.02) between Pts with MCI and those without (resp.>55and <55 mmHg).Conclusion: Elevated PP in treated HT is a risk factor for MCI.We should screen Pts with HT for specific TOD -MCI. P1.09
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.038 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".