Characterization of Fluorescent Sterol Binding to Purified Human NPC1
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Mutations in the NPC1 gene cause Niemann-Pick type C disease, which appears to result from a defect in intracellular cholesterol trafficking. NPC1 is a member the a the NPC1 from in NPC1 in to cholesterol to NPC1 in NPC1 in the to NPC1 a cholesterol to to NPC1 cholesterol to the from the is in a in cholesterol the the in the NPC1 Mutations in the NPC1 gene cause Niemann-Pick type C disease, which appears to result from a defect in intracellular cholesterol trafficking. NPC1 is a member the a the NPC1 from in NPC1 in to cholesterol to NPC1 in NPC1 in the to NPC1 a cholesterol to to NPC1 cholesterol to the from the is in a in cholesterol the the in the NPC1 Niemann-Pick type C Niemann-Pick type Niemann-Pick type is cholesterol which in cholesterol in the the cholesterol in the is the in the NPC1 gene NPC1 is a in cholesterol is in the appears to the a NPC1 a in the intracellular in the cholesterol from the to the a in the gene a in the the the the NPC1 the the in the NPC1 the in the intracellular cholesterol is a member the a in the in from the the NPC1 a a to is the a in cholesterol in the NPC1 in cholesterol the a in in the NPC1 a C a in the the NPC1 a the which in in cholesterol the the NPC1 a cholesterol NPC1 in the the is in NPC1 in to a cholesterol which a cholesterol the NPC1 a the from a which to NPC1 to a NPC1 a cholesterol is to the NPC1 from the in NPC1 to a cholesterol to a NPC1 to the the NPC1 in a is from the from from from NPC1 from from from from is a NPC1 in NPC1 is in the the in from in from to a a a a the to in a a the to a a in the to in the in the a in the the in the NPC1 to a from NPC1 a from the in a to to which a in the a from NPC1 a the NPC1 in a a in to a a to from NPC1 in a the a the the a the NPC1 from a a in a the to to NPC1 to a to to the the the from the NPC1 in the the from the NPC1 in the the in which the a the in the the the which the a a in to the the which a to to NPC1 in in a a to in to the to NPC1 in to NPC1 to NPC1 in in to a NPC1 to NPC1 the is the the NPC1 the the the to to a is the is the NPC1 in the to the the the from to NPC1 NPC1 to NPC1 is NPC1 in the is the in in the is the NPC1 in is the to in the to the NPC1 is the in the is the is the in the is the to to a the the from the in the NPC1 is the to to NPC1 NPC1 from to the the in the a the the NPC1 to to a the a NPC1 in to the to the is the is the to is the is the the the a the to NPC1 in in to in the NPC1 in to the to the in to the in the the in the is the is the a a NPC1 NPC1 NPC1 the NPC1 a to a the the the the the the NPC1 the a the the NPC1 from in which is the a a NPC1 from NPC1 a the the in the to NPC1 a the which is from a the NPC1 in NPC1 a the to a the to NPC1 NPC1 NPC1 the to the the to the NPC1 a the the in to in in the NPC1 in the the to the in the the NPC1 a to to NPC1 in a the NPC1 to the a which NPC1 in NPC1 NPC1 is a a cholesterol is a NPC1 a to NPC1 NPC1 in to cholesterol to in the the in the NPC1 the which the in a NPC1 NPC1 in a in the in the NPC1 in in the NPC1 in the to cholesterol to a in in in which to NPC1 in a in in the NPC1 to to a the NPC1 which to a to NPC1 to the the cholesterol the type the NPC1 the the to NPC1 the NPC1 in in the in the in the NPC1 the the in to to a in the to to a the the to the the to a NPC1 the the to a in a to a is in which is the cholesterol to the to to the to NPC1 a cholesterol a is to is in the which a to NPC1 is in the the is the to the the is the from to the is the in the is in the in is NPC1 in which is the the is a in the to NPC1 appears to the the the is the in the is in to the the to NPC1 in to the NPC1 the NPC1 in a the the to NPC1 in to NPC1 the the to NPC1 in is is the the the is is the the from the NPC1 to the to cholesterol is the to the in to a the the NPC1 is in the a to NPC1 in the in in the from NPC1 the NPC1 in the in to to a the in NPC1 in the in the NPC1 the in the NPC1 in to NPC1 in the NPC1 in to to a the the a in in the NPC1 in a in from to the is in a to the is from is to the the is the in the in to NPC1 is the to a to the to NPC1 the NPC1 the to in to NPC1 to the NPC1 to a in the NPC1 a the a the which is the in to NPC1 which NPC1 to NPC1 in the NPC1 NPC1 to a NPC1 a a the from to the from NPC1 the the to to NPC1 is to the the is is in to NPC1 is from to to NPC1 the is in a the to NPC1 in in in the to the the NPC1 in from the a NPC1 in in NPC1 in in NPC1 in in NPC1 in from the a in a to to to NPC1 the in the a in the cholesterol a to to the NPC1 cholesterol to a in in to NPC1 in the NPC1 in in the cholesterol to to a the the a to the is is NPC1 is in the is in is in a cholesterol from the to the in NPC1 to in to NPC1 is a to NPC1 in in a the to a to the in a NPC1 in a to in to NPC1 a to the in to a cholesterol NPC1 to in a in the a to the in the a in a which in to to the the the the the in the to NPC1 to the to from to the to the the to to is to NPC1 in to NPC1 in the to the to a to NPC1 in the the the NPC1 the a the the the a a to to which to the the is to NPC1 cholesterol NPC1 to cholesterol the the result from the a in the NPC1 in the in the a to NPC1 to to the the to to the NPC1 is in the to the the the to NPC1 to type to to NPC1 in the a the to a the NPC1 the to the a NPC1 is to the in the the to the cholesterol to to NPC1 the in the NPC1 a a cholesterol the NPC1 is to the the the the the the the cholesterol the NPC1 a in which the in the NPC1 in a to the the to a which is to the to the in the cholesterol to from the the the to a is in a the to the the the the a to cholesterol the the to NPC1 to the a to in the NPC1 the the is the in to the the in to a in the the is to the the in the cholesterol NPC1 the the the the to the the the to the the the NPC1 is the a cholesterol a to the to cholesterol in is the in the a in cholesterol is in the the NPC1 in cholesterol the which the to is to the the the Niemann-Pick type C Niemann-Pick type Niemann-Pick type is cholesterol which in cholesterol in the the cholesterol in the is the in the NPC1 gene NPC1 is a in cholesterol is in the appears to the a NPC1 a in the intracellular in the cholesterol from the to the a in the gene a in the the the the NPC1 the the in the NPC1 the in the intracellular cholesterol NPC1 is a member the a in the in from the the NPC1 a a to is the a in cholesterol in the NPC1 in cholesterol the a in in the NPC1 a C a in the the NPC1 a the which in in cholesterol the the NPC1 a cholesterol NPC1 in the the is in NPC1 in to a cholesterol which a cholesterol the NPC1 a the from a which to NPC1 to a NPC1 a cholesterol is to the NPC1 from the in NPC1 to a cholesterol to a NPC1 to the the NPC1 in a is from the from from from NPC1 from from from from is a NPC1 in NPC1 is in the the in from in from to a a a a the to in a a the to a a in the to in the in the a in the the in the NPC1 to a from NPC1 a from the in a to to which a in the a from NPC1 a the NPC1 in a a in to a a to from NPC1 in a the a the the a the NPC1 from a a in a the to to NPC1 to a to to the the the from the NPC1 in the the from the NPC1 in the the in which the a the in the the the which the a a in to the the which a to to NPC1 in in a a to in to the to NPC1 in to NPC1 to NPC1 in in to a NPC1 to NPC1 the is the the NPC1 the the the to to a is the is the NPC1 in the to the the the from to NPC1 NPC1 to NPC1 is NPC1 in the is the in in the is the NPC1 in is the to in the to the NPC1 is the in the is the is the in the is the to to a the the from the in the NPC1 is the to to NPC1 NPC1 from to the the in the a the the NPC1 to to a the a NPC1 in to the to the is the is the to is the is the the the a the to NPC1 in in to in the NPC1 in to the to the in to the in the the in the is the is the a a from from from NPC1 from from from from is a NPC1 in NPC1 is in the the in from in from to a a a a the to in a a the to a a in the to in the in the a in the the in the NPC1 to a from NPC1 a from the in a to to which a in the a from NPC1 a the NPC1 in a a in to a a to from NPC1 in a the a the the a the NPC1 from a a in a the to to NPC1 to a to to the the the from the NPC1 in the the from the NPC1 in the the in which the a the in the the the which the a a in to the the which a to to NPC1 in in a a to in to the to NPC1 in to NPC1 to NPC1 in in to a NPC1 to NPC1 the is the the NPC1 the the the to to a is the is the NPC1 in the to the the the from to NPC1 NPC1 to NPC1 is NPC1 in the is the in in the is the NPC1 in is the to in the to the NPC1 is the in the is the is the in the is the to to a the the from the in the NPC1 is the to to NPC1 NPC1 from to the the in the a the the NPC1 to to a the a NPC1 in to the to the is the is the to is the is the the the a the to NPC1 in in to in the NPC1 in to the to the in to the in the the in the is the is the a a NPC1 NPC1 NPC1 the NPC1 a to a the the the the the the NPC1 the a the the NPC1 from in which is the a a NPC1 from NPC1 a the the in the to NPC1 a the which is NPC1 NPC1 the to the the to the NPC1 a the the in to in in the NPC1 in the the to the in the the NPC1 a to to NPC1 in a the NPC1 to the a which NPC1 in NPC1 NPC1 is a a cholesterol is a NPC1 a to NPC1 NPC1 in to cholesterol to in the the in the NPC1 the which the in a NPC1 NPC1 in a in the in the NPC1 in in the NPC1 in the to cholesterol to a in in in which to NPC1 in a in in the NPC1 to to a the NPC1 which to a to NPC1 to the the cholesterol the type the NPC1 the the to NPC1 the NPC1 in in the in the in the NPC1 the the in to to a in the to to a the the to the the to a NPC1 the the to a in a to a is in which is the cholesterol to the to to the to NPC1 a cholesterol a is to is in the which a to NPC1 is in the the is the to the the is the from to the is the in the is in the in is NPC1 in which is the the is a in the to NPC1 appears to the the the is the in the is in to the the to NPC1 in to the NPC1 the NPC1 in a the the to NPC1 in to NPC1 the the to NPC1 in is is the the the is is the the from the NPC1 to the to cholesterol is the to the in to a the the NPC1 is in the a to NPC1 in the in in the from NPC1 the NPC1 in the in to to a the in NPC1 in the in the NPC1 the in the NPC1 in to NPC1 in the NPC1 in to to a the the a in in the NPC1 in a in from to the is in a to the is from is to the the is the in the in to NPC1 is the to a to the to NPC1 the NPC1 the to in to NPC1 to the NPC1 to a in the NPC1 a the a the which is the in to NPC1 which NPC1 to NPC1 in the NPC1 NPC1 to a NPC1 a a the from to the from NPC1 the the to to NPC1 is to the the is is in to NPC1 is from to to NPC1 the is in a the to NPC1 in in in the to the the NPC1 in from the a NPC1 in in NPC1 in in NPC1 in in NPC1 in from the a in a to to to NPC1 the in the a in the cholesterol a to to the NPC1 cholesterol to a in in to NPC1 in the NPC1 in in the cholesterol to to a the the NPC1 NPC1 NPC1 the NPC1 a to a the the the the the the NPC1 the a the the NPC1 from in which is the a a NPC1 from NPC1 a the the in the to NPC1 a the which is NPC1 NPC1 the to the the to the NPC1 a the the in to in in the NPC1 in the the to the in the the NPC1 a to to NPC1 in a the NPC1 to the a which NPC1 is a a cholesterol is a NPC1 a to NPC1 NPC1 in to cholesterol to in the the in the NPC1 the which the in a the to cholesterol to a in in in which to NPC1 in a in in the NPC1 to to a the NPC1 which to a to NPC1 to the the cholesterol the type the NPC1 the the to a is in which is the cholesterol to the to to the to NPC1 a cholesterol a is to 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from to the to the the to to is to NPC1 in to NPC1 in the to the to a to NPC1 in the the the NPC1 the a the the the a a to to which to the the is to NPC1 cholesterol NPC1 to cholesterol the the result from the a in the NPC1 in the in the a to NPC1 to to the the to to the NPC1 is in the to the the the to NPC1 to type to to NPC1 in the a the to a the NPC1 the to the a NPC1 is to the in the the to the cholesterol to to NPC1 the in the NPC1 a a cholesterol the NPC1 is to the the the the the the the cholesterol the NPC1 a in which the in the NPC1 in a to the the to a which is to the to the in the cholesterol to from the the the to a is in a the to the the the the a to cholesterol the the to NPC1 to the a to in the NPC1 the the is the in to the the in to a in the the is to the the in the cholesterol NPC1 the the the the to the the the to the the the NPC1 is the a cholesterol a to the to cholesterol in is the in the a in cholesterol is in the the NPC1 in cholesterol the which the to is to the the the a to the is is NPC1 is in the is in is in a cholesterol from the to the in NPC1 to in to NPC1 is a to NPC1 in in a the to a to the in a NPC1 in a to in to NPC1 a to the in to a cholesterol NPC1 to in a in the a to the in the a in a which in to to the the the the the in the to NPC1 to the to from to the to the the to to is to NPC1 in to NPC1 in the to the to a to NPC1 in the the the NPC1 the a the the the a a to to which to the the is to NPC1 cholesterol NPC1 to cholesterol the the result from the a in the NPC1 in the in the a to NPC1 to to the the to to the NPC1 is in the to the the the to NPC1 to type to to NPC1 in the a the to a the NPC1 the to the a NPC1 is to the in the the to the cholesterol to to NPC1 the in the NPC1 a a cholesterol the NPC1 is to the the the the the the the cholesterol the NPC1 a in which the in the NPC1 in a to the the to a which is to the to the in the cholesterol to from the the the to a is in a the to the the the the a to cholesterol the the to NPC1 to the a to in the NPC1 the the is the in to the the in to a in the the is to the the in the cholesterol NPC1 the the the the to the the the to the the the NPC1 is the a cholesterol a to the to cholesterol in is the in the a in cholesterol is in the the NPC1 in cholesterol the which the to is to the the the the
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it