407 Chronic-obstructive pulmonary disease (COPD) caused by inhalation of inorganic dust at the workplace - Systematic Review and Metaanalysis
Bibliographic record
Abstract
Objective A systematic review of the scientific medical literature on COPD and the inhalative exposure to inorganic dust and a metaanalysis. Methods The search was done in Medline/EMBASE. The quality of selected papers was evaluated on the basis of the Newcastle-Ottawa Scale and the recommendations of the Cochrane Collaboration. Metaanalysis of the results of pulmonary function tests were evaluated separately for bio-persistent granular dust (BGD) and silica containing dust by random-effects models. Results In cross-sectional analyses subjects occupationally exposed to BGD had on average a 160 ml lower FEV1 and the predicted value for FEV1 was decreased by 5.7%. The ratio of FEV1/FVC was also significantly decreased. Related to a cumulative BGS- exposure of 1 mg/m³·year FEV1 was decreased by 1.6 ml. The Odds Ratio for obstructive pulmonary test results (FEV1/FVC <70%) was 1.07 per 1 mg/m3 BGD at the workplace. Longitudinal analyses showed a yearly decline of FEV1 of 6.3 ml in BGD-exposed and of 11.8 ml in silica exposed persons compared to non/low-exposed persons in addition to age-dependent decline. A study of uranium miners (WISMUT Company) in Germany showed that the cumulative exposure to 1 mg/m3 pure respirable silica dust decreased the ratio of FEV1/FVC by 2.75%. The risk of COPD stage I increased (OR 1.81 pro 1” mg/m3·year) related to the exposure of pure respirable silica dust. In relation to COPD stage II + the cumulative doubling dose was 2 mg/m³·year pure respirable silica dust. All cited results were statistically significant (p < 0.01 to p < 0.001). Funnel plots did not indicate major publication bias. Conclusion Review and metaanalysis showed a statistically positive association between the inhalative exposure to BGD at the workplace and a decreased FEV1 in cross-sectional as well as in longitudinal analyses. Funded by the Federal Ministry of Labour and Social Affairs (“Bundesministerium für Arbeit und Soziales”).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.025 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.016 | 0.028 |
| Bibliometrics | 0.008 | 0.008 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".