Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica‐Coated Au/Fe<sub>2</sub>O<sub>3</sub> Nanoaggregates
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Tumor ablation by thermal energy via the irradiation of plasmonic nanoparticles is a relatively new oncology treatment. Hybrid plasmonic‐superparamagnetic nanoaggregates (50–100 nm in diameter) consisting of SiO 2 ‐coated Fe 2 O 3 and Au (≈30 nm) nanoparticles were fabricated using scalable flame aerosol technology. By finely tuning the Au interparticle distance using the SiO 2 film thickness (or content), the plasmonic coupling of Au nanoparticles can be finely controlled bringing their optical absorption to the near‐IR that is most important for human tissue transmittance. The SiO 2 shell facilitates also dispersion and prevents the reshaping or coalescence of Au particles during laser irradiation, thereby allowing their use in multiple treatments. These nanoaggregates have magnetic resonance imaging (MRI) capability as shown by measuring their r2 relaxivity while their effectiveness as photothermal agents is demonstrated by killing human breast cancer cells with a short, four minute near‐IR laser irradiation (785 nm) at low flux (4.9 W cm ‐2 ).
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it