Adjustment of antihypertensive medication using home based, patient monitored blood pressure reduced both intensity of treatment and blood pressure control
Bibliographic record
Abstract
Staessen JA, Den Hond E, Celis H, et al for the Treatment of Hypertension Based on Home or Office Blood Pressure (THOP) Trial Investigators. Antihypertensive treatment based on blood pressure measurement at home or in the physician’s office: a randomized controlled trial. JAMA 2004;291:955–64.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Is home based, self measurement of blood pressure (BP) more effective than office based, physician measurement as a basis for initiating and titrating antihypertensive drug treatment? ### ![Graphic][5]</img>Design: randomised controlled trial. ### ![Graphic][6]</img>Allocation: concealed. ### ![Graphic][7]</img>Blinding: blinded {patients, physician making treatment decisions, outcome assessors, data analysts, and monitoring committee}*. ### ![Graphic][8]</img>Follow up period: 1 year. ### ![Graphic][9]</img>Setting: 56 primary care practices and 3 hospital based outpatient clinics in Leuven, Belgium and a specialised hypertension clinic in Dublin, Ireland. ### ![Graphic][10]</img>Patients: 400 patients ⩾18 years of age (mean age 53 y, 52% women) who had either untreated or treated hypertension (using ⩽2 antihypertensive agents), and the last of 3 consecutive readings … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.aulast%253DStaessen%26rft.auinit1%253DJ.%2BA.%26rft.volume%253D291%26rft.issue%253D8%26rft.spage%253D955%26rft.epage%253D964%26rft.atitle%253DAntihypertensive%2BTreatment%2BBased%2Bon%2BBlood%2BPressure%2BMeasurement%2Bat%2BHome%2Bor%2Bin%2Bthe%2BPhysician%2527s%2BOffice%253A%2BA%2BRandomized%2BControlled%2BTrial%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.291.8.955%26rft_id%253Dinfo%253Apmid%252F14982911%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.291.8.955&link_type=DOI [3]: /lookup/external-ref?access_num=14982911&link_type=MED&atom=%2Febnurs%2F7%2F3%2F80.atom [4]: /lookup/external-ref?access_num=000189182000023&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".