A randomised controlled trial of total immunosuppression withdrawal in stable liver transplant recipients
Bibliographic record
Abstract
Autoimmune hepatitis triggered by hepatitis AWe describe a case of autoimmune hepatitis triggered by an acute hepatitis A infection.A young woman presented with a 10 day history of nausea and dark urine having returned from Tunisia a month previously.She had marked transaminitis.Viral serology demonstrated positive hepatitis A immunoglobulin M. Other viral serology was negative.Autoantibody screening revealed positive antismooth muscle antibodies (titre 1 in 80) but negative antinuclear (ANA), antimitochondrial, and antiliver, kidney and pancreas (LKM) antibodies.Immunoglobulin levels revealed normal IgA and IgG levels with a raised IgM at 5.53 g/l (range 0.60-2.50).Abdominal ultrasound scan was normal.She was diagnosed with acute hepatitis A.Liver function tests normalised within two months.One month later her alanine aminotransferase levels began to increase.Autoantibody screen was positive for ANA (titre 1 in 40) and SMA was negative.However, immunoglobulin G was raised at 18.6 g/l (range 6-16) and serum electrophoresis showed a polyclonal increase in gamma globulins.Liver histology showed interface portal inflammation with plasma cell (fig 1) associated interface hepatitis with involvement of lobular and perivenular hepatocytes, consistent with autoimmune hepatitis (AIH).She was successfully treated with immunosuppression.Studies suggesting triggering factors for the development of AIH have been reported in the past and include Epstein-Barr virus, 1 and hepatitis B and hepatitis A infection. 2 Although SMA was initially positive in our patient, this was probably because of the viral infection.Using the diagnostic scoring system of the American Association for the Study of Liver Diseases (AASLD) (see table 1) for the diagnosis of AIH, our patient scored 16 before steroid treatment (definite diagnosis is .15)and 18 after steroid treatment (definite diagnosis is .17).The sensitivity of this scoring system for the diagnosis of AIH is quoted by the AASLD as 97-100%.Acute hepatitis secondary to hepatitis A infection is a common cause of viral hepatitis in humans and is usually self limiting and resolves within weeks.However, it may lead to fulminant liver failure in a small percentage of cases.Hepatitis A does not lead to chronic viral hepatitis.We have documented a patient with acute hepatitis A who subsequently went on to develop AIH.Hence diligent follow up of patients with acute hepatitis A needs to be carried out.Hepatitis A may not be, as has long been thought, an acute infection with no long term sequelae.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.010 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".