Bibliographic record
Abstract
CaseWe report a case of a 65-year-old female with an anaphylactic type reaction during a graded oral celecoxib challenge.She was previously using NSAIDS and Celebrex (celecoxib) for analgesia in 2005.However, due to the side effect profile of COX2 inhibitors, Celebrex was discontinued.The patient's primary analgesic was ibuprofen.Upon reintroduction of Celebrex, the patient developed urticaria after the second dose and urticaria with angioedema after the third dose.When the patient presented to the allergy clinic, it was felt that the urticaria and angioedema were secondary to ibuprofen.Because she had a negative crude prick skin test to Celebrex, an oral challenge to Celebrex was done.One hour after the 200 mg cumulative challenge, the patient was asymptomatic and an additional 200 mg was given.Twenty minutes later the patient developed facial flushing, angioedema, respiratory distress and hypotension, with her blood pressure dropping to 78/53 mmHg from a baseline of 120/80 mmHg.The patient was treated with epinephrine 0.1 mg subcutaneously, without recovery.After 5 and 15 minutes additional 0.2 mg subcutaneous epinephrine injections were administered.She was also treated with Reactine 20mg and prednisone 50mg.The patient was stabilized within thirty minutes.The patient was able to tolerate ibuprofen and sulfonamide antibiotics without any side effects.She was also taking hydrochlorothiazide on a daily basis for hypertension.She does not have any previously documented allergies or adverse reactions to medications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".