Comparison of Neuroretinal Rim Area Measurements Made by the Heidelberg Retina Tomograph I and the Heidelberg Retina Tomograph II
Bibliographic record
Abstract
PURPOSE: To investigate the agreement between neuroretinal rim area (RA) measurements using the Heidelberg Retina Tomograph I (HRT Classic) and Heidelberg Retina Tomograph II (HRT II). To compare apparent RA changes in follow-up series of HRT II topographies when using either an HRT Classic or HRT II mean topography as baseline. DESIGN: Cross-sectional study and "no-change," short time series study. PARTICIPANTS: Forty-three ocular hypertensive and 31 primary open angle glaucoma subjects. METHODS: Five HRT Classic and 5 HRT II examinations were acquired from 1 eye of each subject, across 2 visits within 6 weeks. For the cross-sectional study, follow-up RA measurements from HRT Classic and HRT II were compared, using the same HRT Classic mean topography as the baseline. The linear rates of RA change were compared in 2 short time series with either an HRT Classic or an HRT II mean topography as baseline, and 4 follow-up HRT II mean topographies. Intervals between topographies were arbitrarily set at 1 year for meaningful comparisons of rates. Rates of RA change over time were calculated by linear regression. Separate analyses were performed using 3 available reference planes (RP). MAIN OUTCOME MEASURES: Global and sectoral RA measurements in HRT Classic and HRT II mean topographies; linear rates of RA change. RESULTS: HRT Classic minus HRT II mean differences (95% limits of agreement) were 0.09 (-0.17, 0.35) mm, 0.09 (-0.13, 0.32) mm, and 0.11 (-0.24, 0.46) mm for the Moorfields, 320 µm, and standard RPs, respectively (P<0.001 for all RPs, Wilcoxon rank sum test). In the time series, the mean differences (95% limits of agreement) of RA rates of change (HRT Classic baseline minus HRT II baseline) were -0.01 (-0.06, 0.03) mm/y, -0.01 (-0.06, 0.04) mm/y, and -0.0 (-0.09, 0.05) mm/y using the Moorfields, 320 µm, and standard RPs, respectively. CONCLUSION: Although HRT software is backward-compatible, follow-up RA measurements made in the same eye using HRT Classic and HRT II devices display statistically and clinically meaningful systematic differences when HRT Classic topographies are used as a baseline.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".