EFFECT OF RESISTANCE TRAINING ON DISEASE ACTIVITY, MUSCLE, AND BONE IN PATIENTS WITH CROHN??S DISEASE
Bibliographic record
Abstract
Crohn's Disease is an inflammatory bowel disease, which results in a loss of lean tissue and bone mass, possibly because of decreased nutrition and corticosteroid usage. Exercise training is effective in healthy individuals for increasing lean tissue mass and bone mineral density, but there is a fear that it may exacerbate disease activity in patients with Crohn's Disease. PURPOSE The purpose of our study was to evaluate the effect of 7 months of resistance training on disease activity, lean tissue mass, and bone mineral density in patients with Crohn's Disease. METHODS Individuals with Crohn's Disease (in remission) either volunteered to participate in resistance exercise training (EX; 7 females, 3 males, age 41.7y trained for 7 months, 3d/wk, 3 sets of 8–10 reps, 12 exercises) or as control subjects (CNT; 5 females, 1 male, age 52.2y). Disease activity was measured by questionnaire (Harvey and Bradshaw, 1980). Lean tissue mass and bone mineral density (lumbar spine and whole body) were measured by dual energy X-ray absorptiometry. Strength was measured as the 1-repetition maximum on the bench press and leg press in the EX group. RESULTS Disease activity was unchanged in EX and CNT over the 7 months. EX significantly increased lean tissue mass by 0.84 kg (2.2%) (p < 0.05), while CNT had no change (−0.68 kg; −1.9%). There were no changes in lumbar spine (EX: −0.2%; CNT: +0.4%) or whole body (EX: −0.7%; CNT: −0.6%) BMD in either group. EX significantly increased leg press (+37%) and bench press (+25%) strength. CONCLUSION Resistance training in patients with Crohn's Disease results in increases in lean tissue mass and strength, with no effect on disease activity. Seven months of resistance training was insufficient for increasing bone mineral density. Supported by the University of Saskatchewan President's NSERC fund.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".