DISRUPTED PANCREATIC DUCT SYNDROME IN SEVERE ACUTE PANCREATITIS IS NOT A CAUSE OF DEATH
Bibliographic record
Abstract
Background: Disrupted pancreatic duct syndrome (DPDS) is an increasingly recognized complication of severe acute pancreatitis; its natural history, clinical characteristics and outcomes are not very clear. The aim of our study was to describe clinical characteristics and outcomes of a large cohort of DPDS. Methods: Demographic and clinical data were collected from medical records of 45 patients with DPDS, identified from the endoscopy and hospital service database between 1999 and 2006 at our institution. All cases had a partial or complete disruption of the main pancreatic duct identified at ERCP. Results: The median age was 53 years (range 20-83); 51% were men. The most common etiology of acute pancreatitis (AP) was biliary (55%) followed by idiopathic (27%). Four percent of DPDS were located, at the head, 49% at the neck, 27% at the body, and 20% at the tail of the pancreas. Eighty two percent of the cases had a complete pancreatic duct disruption. Fifty one percent resolved after endoscopic treatment, 36% required surgery, 4% resolved spontaneously and 9% persisted. None of these patients died. There was no significant relationship between the etiology of AP, location of DPDS, and endoscopic resolution, need for surgery or number of endoscopic procedures needed; likewise, no significant association between the type of DPDS (partial or complete) and etiology, endoscopic resolution, or the need for surgery was observed. Patients with proximal disruption required ≤3 endoscopic procedures compared with their distal counterparts (p = 0.05), however this was not associated with any significant change in endoscopic resolution rate nor increased need for surgery (p = 0.8 and p = 0.7; respectively). Conclusions: DPDS mainly occurs at the proximal pancreas. Proximal DPDS required less endoscopic interventions compared with its distal counterparts. DPDS did not lead to mortality in patients with severe acute pancreatitis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".