An injectable aldehyded 1-amino-3,3-diethoxy-propane hyaluronic acid–chitosan hydrogel as a carrier of adipose derived stem cells to enhance angiogenesis and promote skin regeneration
Bibliographic record
Abstract
We report an injectable aldehyded 1-amino-3,3-diethoxy-propane (ADEP)-hyaluronic acid (AHA)-chitosan (CS) hydrogel. This hydrogel can enhance wound healing by promoting cell migration, proliferation, granulation and angiogensis. During sol-gel transition, no chemical crosslinking agent was introduced and the structure of polysaccharide HA was grafted with a functional molecule, 1-amino-3,3-diethoxy-propane, but without using oxidation to break the HA structure as previously reported. Rheological tests showed the injectability and stability of this AHA-CS hydrogel. Full thickness skin defects (1 cm × 1 cm) were made on mice and the adipose derived stem cell loaded gel was tested in the healing-impaired wound. The AHA-CA hydrogel significantly accelerated wound closure, increased cell proliferation (Ki67 marker) and promoted keratinocyte migration (p63 marker). Histological examination demonstrated that the gel significantly advanced granulation tissue and capillary formation in the gel-treated wounds. mRNA expressions of angiogenesis (VEGF-A), chemotactic factors (SDF-1) and ECM-remodeling MMPs (MMP1 and MMP9) were also up-regulated in the hydrogel-treated wounds.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".