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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

2015· article· en· 711 citations· W2051921450 on OpenAlex· 10.1038/nm.3855

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.020
GPT teacher head0.284
Teacher spread
0.264 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Medicine
Topic
Glioma Diagnosis and Treatment
Field
Medicine
Canadian institutions
University of Toronto
Funders
National Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institutes of HealthJohns Hopkins UniversityCure Starts Now FoundationUniversity of WarwickNorthwestern UniversityU.S. Department of DefenseOregon Health and Science UniversityReflections of Grace FoundationNational Science FoundationVirginia and D.K. Ludwig Fund for Cancer ResearchAlex's Lemonade Stand Foundation for Childhood CancerCureSearch for Children's Cancer
Keywords
PanobinostatCancer researchDemethylaseGliomaHistone deacetylaseHistone deacetylase inhibitorMedicineHistoneBiologyGeneticsGene
Has abstract in OpenAlex
no