Controlled Association of Amphiphilic Polymers in Water: Thermosensitive Nanoparticles Formed by Self-Assembly of Hydrophobically Modified Pullulans and Poly(<i>N</i>-isopropylacrylamides)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Thermoresponsive hydrogel nanoparticles were prepared by self-assembly of two different hydrophobically modified polymers, namely a cholesterol-bearing pullulan (CHP) and a copolymer of N -isopropylacrylamide (NIPAM) and N -[4-(1-pyrenyl)butyl]- N - n -octadecylacrylamide] (PNIPAM-C 18 Py). The interactions between CHP and PNIPAM-C 18 Py were investigated by fluorescence spectroscopy, dynamic light scattering, and size exclusion chromatography. After ultrasonication of a mixture of CHP and PNIPAM-C 18 Py (5:1 by weight) at 25 °C, monodisperse nanoparticles (Dh = 45 nm) were obtained, consisting of self-assembly of the two polymers associated via their hydrophobic moieties. Evidence from fluorescence and dynamic light scattering demonstrated that, above 32 °C, the lower critical solution temperature (LCST) of PNIPAM-C 18 Py, the colloidal mixed nanoparticles increase in diameter (from 47 to 160 nm), but no macroscopic aggregation could be detected. This phenomenon was thermoreversible: upon cooling the particles recovered their original diameter.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it