Bonzo/CXCR6 expression defines type 1–polarized T-cell subsets with extralymphoid tissue homing potential
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- 0.266 · how far apart the two teachers sit on this one work
- Validation status
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Abstract
Chemokine receptor expression is finely controlled during T-cell development. We show that newly identified chemokine receptor Bonzo/CXCR6 is expressed by subsets of Th1 or T-cytotoxic 1 (Tc1) cells, but not by Th2 or Tc2 cells, establishing Bonzo as a differential marker of polarized type 1 T cells in vitro and in vivo. Priming of naive T cells by dendritic cells induces expression of Bonzo on T cells. IL-12 enhances this dendritic cell-dependent upregulation, while IL-4 inhibits it. In blood, 35-56% of Bonzo+ CD4 T cells are Th1 cells, and 60-65% of Bonzo+ CD8 T cells are Tc1 cells, while few Bonzo+ cells are type 2 T cells. Almost all Bonzo+ Tc1 cells contain preformed granzyme A and display cytotoxic effector phenotype. Most Bonzo+ T cells lack L-selectin and/or CCR7, homing receptors for lymphoid tissues. Instead, Bonzo+ T cells are dramatically enriched among T cells in tissue sites of inflammation, such as rheumatoid joints and inflamed livers. Bonzo may be important in trafficking of effector T cells that mediate type 1 inflammation, making it a potential target for therapeutic modulation of inflammatory diseases.
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The record
- Venue
- Journal of Clinical Investigation
- Topic
- T-cell and B-cell Immunology
- Field
- Immunology and Microbiology
- Canadian institutions
- —
- Funders
- National Institutes of HealthYork UniversityLeukemia and Lymphoma SocietyNational Institute of Allergy and Infectious DiseasesU.S. Department of Veterans Affairs
- Keywords
- Cytotoxic T cellInterleukin 21Natural killer T cellCell biologyIL-2 receptorCD40CXCL16CCL5ZAP70Antigen-presenting cellGranzyme BHoming (biology)T cellCXCR3BiologyGranzymeC-C chemokine receptor type 7Interleukin 12CD28Priming (agriculture)CD8Chemokine receptorChemokineImmunologyInflammationImmune systemPerforinIn vitro
- Has abstract in OpenAlex
- yes