[P227]: Sensory compensation in the blind mouse: Comparison between congenital anophthalmia and early enucleation in mice raised in enriched or standard environment
Bibliographic record
Abstract
Various studies demonstrate activity in occipital cortex, normally visual, in blind person undergoing auditory or sensitive task. This compensation appears mainly after early visual deprivation. This supports the hypothesis of a reorganization of sensory pathways in those people. Which structures are involved in this reorganization and will environment influence it? We investigated those issues by studying two animal models: a mutant ZRDCT/An mouse strain in which neither the retina nor the optic nerve develop, and a C57BL/6 mouse enucleated at birth. Some normal eyed C57 mice served as controls. Both strains were grown in standard or enriched environments. We used c-Fos immunohistochemistry on coronal sections to reveal the structures activated by auditory stimuli. All animals had their whiskers trimmed to limit somatosensory activation and were placed in a noise attenuated chamber before the experiment. The next morning, while a few controls remained unstimulated, the other mice were submitted to white noise bursts for 1 h. In addition to the label normally found in the auditory structures, we observed in mutant mice immunolabelled nuclei in the visual thalamus – the dorsal lateral geniculate nucleus (dLGN) – and in V1 mainly and V2. In enucleated mice, we observed labelled nuclei mainly in V2 but also in V1. No labelled cell could be found in the visual thalamus. The significance influence of the environment is observed in a few structures only: in IC, LGNd and AC. Tracing studies using dextran–biotin injections in the inferior colliculus (IC) of mice confirmed the difference between ZRDCT/An and C57 enucleated at birth: while the first group shows IC projections entering both LGN and LP, in the second, auditory fibers were found only within LP; none were found in eyed controls. Support contributed by NSERC and NATEQ.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.004 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.008 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".