Hydrogels of Thermoreversible Comb‐Polymers Exhibit Increased Resistance for Dissolution
Bibliographic record
Abstract
Abstract The N‐isopropylacrylamide (NiPAM) polymers exhibit thermoreversible properties in aqueous solutions. The resiliency of NiPAM hydrogels is believed to influence the outcome when the polymers are utilized in biomedical applications. To determine the influence of polymer architecture on hydrogel resiliency, polymers of NiPAM, methyl methacrylate (MMA) and acrylic acid were synthesized as random polymers and as comb polymers, where MMA was incorporated as side‐chains. Random polymers exhibited a Lower Critical Solution Temperature (LCST) that decreased in proportion to MMA content in polymers. The LCST of comb polymers was not dependent on MMA content or the length of MMA side‐chain (between 3.0 and 10.1 kD). Whereas low molecular weight (∼100 kD) random polymers did not form intact gels, comb‐polymers of equivalent molecular weight were capable of forming intact gels. Gel resiliency, as determined by propensity of hydrogels to dissolve upon cooling, was improved when the molecular weight of comb‐polymers was increased but the length of the MMA side‐branch did not influence the gel resiliency. We conclude that hydrogel dissolution was dependent on polymer architecture as well as the polymer molecular weight.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".