Age-Dependent Effect of Domperidone on Dopamine Release by the Hypoxic Carotid Body in the Rabbit
Bibliographic record
Abstract
The aim of this study was to identify the mechanisms that regulate dopamine release (DA<sub>r</sub>) by the hypoxic carotid body (CB) during development. CBs sampled from adult (n = 58) and 10-day-old (n = 53) rabbits were incubated for 1 h in a medium equilibrated with 8% O<sub>2</sub> in N<sub>2</sub> without or in the presence of the specific DA D<sub>2</sub> receptor antagonist domperidone, 0.01, 0.1 and 1 µ<i>M</i>. DA and its major metabolite DOPAC were measured in the CB (DA<sub>CB</sub>) and in the medium (DA<sub>r</sub>) by HPLC+ED. In adults, each concentration of domperidone significantly decreased DA<sub>CB</sub> and increased DA<sub>r</sub>, compared with control (p < 0.01). In contrast, in 10-day old, only the 1 µ<i>M</i> domperidone concentration decreased DA<sub>CB</sub> and increased DA<sub>r</sub> compared with control (p < 0.001). The data show that domperidone increases CB DA<sub>r</sub> in response to hypoxia in a concentration- and age-dependent manner and suggest this response depends, in part, on the functional maturation of CB DA D<sub>2</sub> receptors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".