Typical clinical doses of methylphenidate did not cause tics or exacerbate pre-existing tics in children with attention deficit hyperactivity disorder
Bibliographic record
Abstract
Law SF, Schachar RJ. Do typical clinical doses of methylphenidate cause tics in children treated for attention-deficit hyperactivity disorder? J Am Acad Child Adolesc Psychiatry1999 Aug; 38 : 944 –51. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In children treated for attention deficit hyperactivity disorder (ADHD), do typical clinical doses of methylphenidate (MPH) cause tics or exacerbate pre-existing mild to moderate tics? Non-randomised, blinded (patients and outcome assessors)*, placebo controlled trial with 1 year of follow up. Children were originally randomised to the intervention groups but crossovers were maintained and analysed in the group they crossed over to. The Hospital for Sick Children, Toronto, Ontario, Canada. 91 children (mean age 8 y, 81% boys) with ADHD with and without comorbid tics who had no previous medication for ADHD or tics. Children had to have a history of ADHD symptoms for ≥6 months beginning before … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bthe%2BAmerican%2BAcademy%2Bof%2BChild%2Band%2BAdolescent%2BPsychiatry%26rft.stitle%253DJ%2BAm%2BAcad%2BChild%2BAdolesc%2BPsychiatry%26rft.aulast%253DLaw%26rft.auinit1%253DS.%2BF.%26rft.volume%253D38%26rft.issue%253D8%26rft.spage%253D944%26rft.epage%253D951%26rft.atitle%253DDo%2Btypical%2Bclinical%2Bdoses%2Bof%2Bmethylphenidate%2Bcause%2Btics%2Bin%2Bchildren%2Btreated%2Bfor%2Battention-deficit%2Bhyperactivity%2Bdisorder%253F%26rft_id%253Dinfo%253Adoi%252F10.1097%252F00004583-199908000-00009%26rft_id%253Dinfo%253Apmid%252F10434485%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1097/00004583-199908000-00009&link_type=DOI [3]: /lookup/external-ref?access_num=10434485&link_type=MED&atom=%2Febmental%2F3%2F1%2F31.atom [4]: /lookup/external-ref?access_num=000081664700009&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".