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Transfusion related acute lung injury (TRALI)

2005· letter· en· W2055566240 on OpenAlexaboutno aff
S. J. Urbaniak

Bibliographic record

VenueBritish Journal of Haematology · 2005
Typeletter
Languageen
FieldMedicine
TopicBlood transfusion and management
Canadian institutionsnot available
Fundersnot available
KeywordsTransfusion-related acute lung injuryMedicineSeriousnessIntensive care medicineConsensus conferenceAcute respiratory distressChest radiographBlood transfusionLungInternal medicinePulmonary edema

Abstract

fetched live from OpenAlex

The feature Images in Haematology on Transfusion-Related Acute Lung Injury (Quinn & Murphy, 2005) is a timely reminder of the seriousness and severity of this condition. The clinical features and accompanying radiograph is a classical description of the features required to make the diagnosis, and is fully in agreement with the Canadian Consensus definition recently agreed (Kleinman et al (2004), and the accepted clinical definition of acute lung injury (ALI), as proposed by the American-European Consensus Committee on adult respiratory distress syndrome (Bernard et al (1994). However, there is a significant error in the recommendation made by the authors in suggesting that 21 h is the cut-off point after transfusion. The Canadian Consensus meeting (Kleinman et al, 2004) gives 1 h after a transfusion as the time limit for transfusion associated ALI. Data for the UK Serious Hazards of Transfusion (SHOT) reporting system (Goldman et al, 2005) confirm that 91% of TRALI cases occur within 1 h, with criteria that predate the Consensus meeting (Kleinman et al, 2004). This may seem a relatively trivial distinction, but the confirmed diagnosis of TRALI is entirely clinical, with laboratory investigation being focussed on identifying implicated donor/donations, not confirming the diagnosis. Presumptive diagnosis of TRALI on loose criteria diverts important resources toward inappropriate investigations, and the potential unnecessary exclusion of donors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.141
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.004
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.260
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations34
Published2005
Admission routes1
Has abstractyes

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