The Effects of Extracts from St. John's Wort and Kava Kava on Brain Neurotransmitter Levels in the Mouse
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Bibliographic record
Abstract
Extracts of Hypericum perforatum (St. John's Wort, SJW) and Kava Kava are well established in the treatment of psychiatric disorders. Several controlled clinical studies have confirmed that SJW extract represents an effective antidepressant principle superior to placebo [13] [18] [19]. SJW extract contains at least ten constituents or groups of components that may contribute to its pharmacological effects [4]. SJW extracts have been shown to inhibit synaptosomal uptake of serotonin, dopamine and noradrenaline, implying a biochemical mechanism similar to classical antidepressants [14] [15]. The reuptake inhibiting properties of SJW extract have mostly been attributed to the phloroglucinol derivative, hyperforin [15]; see also Wonnemann et al., this issue.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it