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Record W2057398976 · doi:10.1053/j.gastro.2012.12.020

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis

2012· review· en· W2057398976 on OpenAlexafffund
Ulrike Peters, Shuo Jiao, Fredrick R. Schumacher, Carolyn M. Hutter, Aaron K. Aragaki, John A. Baron, Sonja I. Berndt, Stéphane Bezieau, Hermann Brenner, Katja Butterbach, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang‐Claude, Stephen J. Chanock, Lin Chen, Gerhard A. Coetzee, Simon G. Coetzee, David V. Conti, Keith R. Curtis, David Duggan, Todd L. Edwards, Charles S. Fuchs, Steven Gallinger, Edward L. Giovannucci, Stephanie M. Gogarten, Stephen B. Gruber, Robert W. Haile, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, David J. Hunter, Rebecca D. Jackson, Sun Ha Jee, Mark A. Jenkins, Wei–Hua Jia, Laurence N. Kolonel, Charles Kooperberg, Sébastien Küry, Andrea Z. LaCroix, Cathy C. Laurie, Cecelia Laurie, Loı̈c Le Marchand, Mathieu Lemire, David Levine, Noralane M. Lindor, Yan Liu, Jing Ma, Karen W. Makar, Keitaro Matsuo, Polly A. Newcomb, John D. Potter, Ross L. Prentice, Conghui Qu, Thomas E. Rohan, Stephanie A. Rosse, Robert E. Schoen, Daniela Seminara, Martha J. Shrubsole, Xiao‐Ou Shu, Martha L. Slattery, Darin Taverna, Stephen N. Thibodeau, Cornelia M. Ulrich, Emily White, Yong‐Bing Xiang, Brent W. Zanke, Yi‐Xin Zeng, Ben Zhang, Wei Zheng, Li Hsu

Bibliographic record

VenueGastroenterology · 2012
Typereview
Languageen
FieldMedicine
TopicGenetic factors in colorectal cancer
Canadian institutionsUniversity of OttawaUniversity of TorontoOntario Institute for Cancer ResearchToronto General Hospital
FundersNational Cancer InstituteNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteNational Key Research and Development Program of ChinaJapan Society for the Promotion of ScienceCanadian Institutes of Health ResearchGroupement des Entreprises Françaises dans la lutte contre le CancerMinistero dello Sviluppo EconomicoDivision of Cancer Prevention, National Cancer InstituteNational Institute on AgingMinistry of Education, Culture, Sports, Science and TechnologyCanadian Cancer Society Research InstituteSchool of Medicine, Vanderbilt UniversityDeutsche ForschungsgemeinschaftOntario Ministry of Economic Development and InnovationOntario Research FoundationJohns Hopkins UniversityBundesministerium für Bildung und ForschungDivision of Cancer Epidemiology and Genetics, National Cancer InstituteAssociation Anne de Bretagne GenetiqueConseil Régional des Pays de la LoireOntario Institute for Cancer ResearchNational Institutes of HealthU.S. Department of Health and Human ServicesVanderbilt-Ingram Cancer CenterVanderbilt University
KeywordsLocus (genetics)BiologyGeneticsSingle-nucleotide polymorphismColorectal adenomaColorectal cancerAlleleGenome-wide association studyGeneCancerGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.007
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.084
GPT teacher head0.347
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations341
Published2012
Admission routes2
Has abstractno

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