The efficacy of continuous versus intermittent celecoxib treatment in osteoarthritis patients aged <60 and ≥60 years
Bibliographic record
Abstract
Aim: To characterize the effect of age on the efficacy of continuous versus intermittent celecoxib treatment. Materials & methods: Prespecified exploratory analysis of a double-blind, parallel-group, randomized, multicenter international study. A total of 858 patients with osteoarthritis of the knee or hip were randomized to receive celecoxib 200 mg/day either as continuous or intermittent treatment. Efficacy was measured by the Western Ontario and McMaster Universities Osteoarthritis Index total and subscale scores, and the number of flare events. Results: Least squares mean increases (worsening) in Western Ontario and McMaster Universities Osteoarthritis Index total scores were significantly less in the continuous than in the intermittent treatment group in patients aged <60 years (1.10 vs 5.32; p = 0.002). In patients aged ≥60 years, the difference between treatment groups was not significant (2.24 vs 4.60; p = 0.111). Fewer flares were reported in the continuous than in the intermittent treatment grou...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".