066 Fixation of Autologous Skin Grafts Without Staples or Sutures – Experimental Study
Bibliographic record
Abstract
The objective of the study was to evaluate the efficacy of skin graft fixation with fibrin sealant (FS) alone by means of spray application with a low setting time (thrombin concentration 4–5 IU/ml) in comparison to point suture fixation as a clinical reference method. Furthermore, the influence of two different quantities of FS were tested. Material and Methods : On the dorsum of 6 male pigs four full‐thickness wounds (8 × 4 cm) were excised in each animal. Randomly the four defects were divided into 3 groups (FS 0.05 ml/cm 2 ; FS 0.15 ml/cm 2 (Tisseel, Baxter AG, Vienna, Austria); Suture) and covered with autologous split thickness skin grafts. Outcome measurements included hematoma/seroma formation, graft dislocation, wound contraction, graft take rate and healed wound area. Observational time points were the 5 th , 14 th and 21 st postoperative day. Results : Hematoma formation on day of surgery was more pronounced in the suture group (FS 0.05 ml/cm 2 vs. suture, p < 0.05), similar the situation on the 5 th postoperative day but without statistical significance. Graft dislocation revealed marked but not significant extended area in the suture group vs. the FS 0.05 ml/cm 2 group. The FS 0.05 ml/cm 2 graft take on day 5 was found to be enhanced in comparison to the suture group. Excellent wound healing was notable on final observation day in the FS 0.05 ml/cm 2 group with a healed wound area of 99.7 (3.6/0.3). Corresponding values in the FS 0.15 ml/cm 2 was 96.9 (4.7/2.1) and 95.9 (2.7/2.1) for the suture group. Values represents median (Q1/Q3). Conclusion : The application of a thin layer of FS (0.05 ml/cm 2 ) in a low setting rate (4–5 IU thrombin) in split thickness skin transplantation via a spray device shows comparable results to those yielded with suture point fixation (surrogate for staples). Advantages are e.g. better cosmetic results and initial hemostasis with minimizing the incidence of early hematoma formation. Equal properties of manufactured low thrombin (4 IU; Canada) preparation vs. 500 IU (US) diluted to a 5 IU thrombin solution was also demonstrated.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".