Effects of Acute Exercise on Neutrophils in Pediatric Acute Lymphoblastic Leukemia Survivors: A Pilot Study
Bibliographic record
Abstract
PURPOSE: This nonrandomized controlled trial was designed to investigate the effects of acute exercise on neutrophil count and function in children and adolescents receiving maintenance treatment for acute lymphoblastic leukemia (ALL) compared to matched controls. METHODS: Participants (n = 10; 4 ALL patients and 6 healthy matched controls) were males between the ages of 7 to 18 years. On visit 1, participants completed an incremental exercise test to volitional exhaustion on a treadmill to determine peak aerobic fitness (VO(2peak)). On visit 2, participants completed a 30-minute exercise session consisting of an intermittent run-walk on a treadmill at 70% to 85% of VO(2) peak with blood sampling completed at 5 time points: fasting, preexercise, postexercise, 1-hour postexercise, and 2-hour postexercise. RESULTS: A significant increase in absolute neutrophil count from preexercise to postexercise was observed in both groups (P = 0.011). Neutrophil oxidative capacity was significantly depressed in the ALL group at the basal level (P = 0.029), however, it increased in both groups after exercise and stimulation. CONCLUSIONS: This preliminary study suggests that 30 minutes of moderate intensity exercise in ALL patients receiving maintenance therapy provides a similar neutrophil response to that of healthy age and sex-matched controls.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".