Effect of Inhaling 100% O <sub>2</sub> on Ventilation and Acid-Base Balance in Cerebrospinal Fluid of Neonates
Bibliographic record
Abstract
If 100% O<sub>2</sub> produces hyperventilation by increasing central CO<sub>2</sub> due to cerebral vasoconstriction or diminished reduction of oxyhemoglobin, then, there should be a parallel decrease in alveolar and CSF PCO<sub>2</sub> during O<sub>2</sub> breathing in neonates. To test this hypothesis, we measured ventilation, alveolar PCO<sub>2</sub> and CSF PCO<sub>2</sub>, pH and HCO<sub>2</sub> before and 10–20 min after infants began breathing 100% O<sub>2</sub>. With 100% O<sub>2</sub>, minute ventilation increased from 0.193 ± (SE) 0.013 (n = 7) to 0.252 ± 0.013 liter/min/kg (p < 0.015), P<sub>A</sub>CO<sub>2</sub> decreased from 42 ± 2 to 38 ± 2 mm Hg (p < 0.005), CSF PCO<sub>2</sub> decreased from 51 ± 1 to 44 ± 1 mm Hg (p < 0.015), and pH increased from 7.308 ± 0.013 to 7.354 ± 0.013 (p < 0.05). CSF bicarbonate decreased, but not significantly. These findings, showing a trend toward alkalosis, suggest that the neonate, like the adult man, induces hyperventilation during hyperoxia via an increase in PCO<sub>2</sub> at the central level.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".