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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004· article· en· 1,864 citations· W2060814375 on OpenAlex· 10.1038/nature02789

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Sirtuins and Resveratrol in Medicine
Field
Medicine
Canadian institutions
Funders
National Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on AgingNational Institutes of HealthNational Center for Research ResourcesNational Institute of General Medical SciencesUniversity of British ColumbiaUniversity of Connecticut
Keywords
SirtuinCaenorhabditis elegansDrosophila melanogasterBiologySaccharomyces cerevisiaeCaloric theoryModel organismNAD+ kinaseAgeingSIRT2GeneticsCell biologyLongevityFecundityResveratrolSirtuin 1SenescenceMelanogasterDrosophila (subgenus)YeastGeneBiochemistryEnzymeMedicinePopulation
Has abstract in OpenAlex
no