Usefulness of Bromocriptine in the Treatment of Amisulpride-induced Hyperprolactinemia
Why this work is in the frame
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Bibliographic record
Abstract
We investigated the effect of bromocriptine on amisulpride-induced endocrinological disturbances (galactorrhea/amenorrhea) and on psychotic symptoms in an open-labeled study. Five women suffering from chronic psychosis and amisulpride-induced hyperprolactinemia (AIH) with amenorrhea and/or galactorrhea received bromocriptine at a dose of 10-40 mg/day. In none of these patients could prolactin levels be reduced to the normal range. They were markedly reduced in three of five patients. Menses recurred in one of four patients with amenorrhea. Lactation decreased in one of three patients with galactorrhea. In two patients with reduced prolactin levels, psychotic symptoms exacerbated but fully remitted after discontinuation of bromocriptine therapy. Thus, bromocriptine seems to annihilate the central effect of amisulpride at a dose that reduces AIH. Therefore, bromocriptine appears not to be suited for the treatment of AIH.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it