2288 PROGNOSTIC IMPACT OF INHERITED GENETIC VARIATIONS IN SRD5A AND ANDROGEN INACTIVATING UGT2B GENES IN PROSTATE CANCER AFTER PROSTATECTOMY
Bibliographic record
Abstract
You have accessJournal of UrologyProstate Cancer: Markers1 Apr 20112288 PROGNOSTIC IMPACT OF INHERITED GENETIC VARIATIONS IN SRD5A AND ANDROGEN INACTIVATING UGT2B GENES IN PROSTATE CANCER AFTER PROSTATECTOMY Yves Fradet, Etienne Audet-Walsh, Judith Bellemare, Geneviève Nadeau, Louis Lacombe, Pierre Douville, Hugo Girard, Chantal Guillemette, and Eric Lévesque Yves FradetYves Fradet Quebec, Canada , Etienne Audet-WalshEtienne Audet-Walsh Quebec, Canada , Judith BellemareJudith Bellemare Quebec, Canada , Geneviève NadeauGeneviève Nadeau Quebec, Canada , Louis LacombeLouis Lacombe Quebec, Canada , Pierre DouvillePierre Douville Quebec, Canada , Hugo GirardHugo Girard Quebec, Canada , Chantal GuillemetteChantal Guillemette Quebec, Canada , and Eric LévesqueEric Lévesque Quebec, Canada View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2533AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The relationship between genetic variations in androgen biosynthesis (SRD5A) and inactivating (UGT2B) genes and the risk of biochemical recurrence (BCR) after prostatectomy remains an unexplored area. METHODS We studied a cohort of 526 men with organ-confined and locally advanced cancer with a median follow-up of 7.4 years. RESULTS After adjusting for all clinicopathologic risk factors, we found a strong association between the risk of BCR and 7 SNPs in SRD5A genes. The combination of 2 SNPs respectively in SRD5A 1 and SRD5A 2 were highly favourable, reducing drastically the risk of BCR for carriers of 3–4 alleles (HR=0.34; 95% CI=0.18–0.64; P=9×10-4). Other variations in the SRD5A 2 gene were associated with an increased rate of BCR, namely the cSNPs rs523349 with a HR of 2.12 (95% CI, 1.21–3.75; P=0.009) and reaching 4.97 when combined with deleted copies of UGT2B genes (95% CI, 2.38–10.36; P=0.00002). Further, BCR-free survival rate was significantly reduced to 27% in patients with unfavourable genotypes compared to 75% for patients with favourable genotypes (P=7×10–6). CONCLUSIONS In conclusion, inherited polymorphisms in the SRD5A and UGT2B genes are independent predictors of biochemical recurrence after radical prostatectomy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e917-e918 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yves Fradet Quebec, Canada More articles by this author Etienne Audet-Walsh Quebec, Canada More articles by this author Judith Bellemare Quebec, Canada More articles by this author Geneviève Nadeau Quebec, Canada More articles by this author Louis Lacombe Quebec, Canada More articles by this author Pierre Douville Quebec, Canada More articles by this author Hugo Girard Quebec, Canada More articles by this author Chantal Guillemette Quebec, Canada More articles by this author Eric Lévesque Quebec, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".