Major gene effect on subcutaneous fat distribution in a sedentary population and its response to exercise training: The HERITAGE Family Study
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Complex segregation analysis of baseline subcutaneous fat distribution and the change in response to exercise training (post-training minus baseline indices) was performed in a sample of 482 individuals from 99 Caucasian families who participated in the HERITAGE Family Study. The sum of skinfold (SF) thicknesses at eight sites, and the waist and hip circumferences were measured at baseline and after completing a 20-week exercise training program. The trunk-to-extremity ratio (TER) was calculated by dividing the sum of skinfold thicknesses at four trunk sites (subscapular + suprailiac + abdominal + midaxillary) by the sum of skinfold thicknesses at four extremity sites (triceps + biceps + medial calf + thigh). While SF was used to assess total subcutaneous adiposity, TER and the ratio of the waist-to-hip circumferences (WHR) were used to characterize subcutaneous fat distribution. Baseline TER and WHR were age-adjusted and age-SF-adjusted within four sex-by-generation groups. The changes of SF, TER, and WHR in response to training were adjusted for age effects alone and for the effects of age and baseline values. Baseline SF was influenced by a multifactorial component (30%) plus a major effect that may be environmental in origin accounting for 47% of the variance. Baseline TER was influenced by a multifactorial component (18%) and a major codominant gene (q(2) = 0.10), which accounted for 56% of the variance. The major gene effect was independent of total subcutaneous adiposity. Baseline WHR was regulated by a major codominant gene (q(2) = 0.15), which accounted for 48% of the variance. However, this major gene effect for baseline WHR should be interpreted with caution, given the estimates of the tau's under the general model. No familial effect was found for the changes in response to training for these subcutaneous adiposity and fat distribution phenotypes. Am. J. Hum. Biol. 12:600-609, 2000. Copyright 2000 Wiley-Liss, Inc.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it