Antimicrobial susceptibility and combination testing of invasive<i>Stenotrophomonas maltophilia</i>isolates
Why this work is in the frame
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Bibliographic record
Abstract
BACKGROUND: Treatment of invasive Stenotrophomonas maltophilia infections is difficult due to this organism's inherent multidrug resistance and increasing resistance to trimethoprim-sulfamethoxazole via acquisition of the sul genes. METHODS: In vitro antibiotic susceptibility testing was performed using a customized broth microdilution panel. Combination testing for tigecycline with anti-Stenotrophomonas agents (i.e. colistin, ticarcillin-clavulanate, ceftazidime, and levofloxacin) was done using the cross Etest method. Genotyping was done using automated repetitive PCR. RESULTS: A total of 90 patients with invasive S. maltophilia infections included: (79%) adults, and 21% children or infants [6/12 (50%) cases occurred in infants aged ≤ 1 year.]. S. maltophilia isolates were recovered from blood (69%), lower respiratory (21%) or other sites (CSF, peritoneal fluid) (11%). Seventeen percent of the isolates were SXT-R, and also demonstrated multi-drug resistant to two or more antibiotic classes. Minocycline, tigecycline and colistin had the best in vitro activities. The combination testing of tigecycline and colistin gave the best results; 12 isolates were tested and synergy occurred in 3 isolates while an additional 7 isolates showed additive results. CONCLUSIONS: We recommend further evaluation with killing assays and clinical studies to evaluate the effectiveness of tigecycline and colistin combination for invasive S. maltophilia infections.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it